CORDIS Project
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This project aims to clarify the structure and function of ribosomes by producing high-resolution crystal structures of yeast and human ribosome complexes. The research focuses on understanding the mechanisms of molecular translocation involving tRNA and mRNA during protein synthesis.
This project will elucidate the structure and mechanism of ribosome function through the determination of high resolution crystal structures of human ribosome functional complexes.
Currently, the only high resolution crystal structures available for the ribosome functional complexes are bacterial ribosomes containing mRNA, tRNAs in E, P and A sites and several translation factors.
Recently, we have determined at medium resolution the first eukaryotic ribosome structure.
Saccharomyces cerevisaia…
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
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