CORDIS Project
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This project focuses on understanding the assembly and function of centrioles, which are vital for cell organization and division. By studying specific proteins involved in centriole formation, it aims to uncover how mutations affect their structure and function, contributing to diseases like cancer.
The centriole is a conserved organelle essential for cell organisation, division and motility through its capacity to organise microtubules. A broad range of human diseases, such as microcephaly and cancer, have been associated with defects in centriole formation, making the full characterisation of its assembly process of great interest.
Centrioles are miniature cylinders of characteristic symmetry, diameter and length, yet the molecular methods by which these parameters are defined are only pa…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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