CORDIS Project
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This project focuses on developing new methods for creating bioisosteric replacements of aromatic compounds in drug candidates. By utilizing innovative catalytic techniques, the aim is to enhance the metabolic stability and bioactivity of these compounds, leading to safer and more effective pharmaceuticals.
The concept of bioisosteric replacement of arene pharmacophores in drug candidates has garnered increasing attention as a powerful tool to circumvent the production of toxic metabolites through detrimental metabolic modifications of the arene backbone.
Replacement of the arene core in drug candidates with rigid, C(sp3)-rich bioisosteric scaffold improves their metabolic stability, potency, lipophilicity, and solubility.
Crucially, cage-like structures with defined exit vectors renders them biois…
THE UNIVERSITY OF MANCHESTER
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