CORDIS Project
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This project explores the structural differences between AMPA and kainate receptors, which are crucial for fast synaptic transmission. It aims to identify how these receptors' desensitization mechanisms differ through various experimental approaches.
AMPA and kainate receptors mediate fast excitatory synaptic transmission. AMPA receptor ligand-binding domains form dimers, which are well-known to control ion channel activation and desensitization.
The dimer stability is related to the rate and extent of desensitization.
Despite the similarity in structure between AMPA and kainate receptors, they present a clear difference in function, suggesting that specific interactions governing gating differ between these two subtypes.
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