CORDIS Project
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This project focuses on the RZZ protein complex, essential for proper chromosome alignment during cell division. By characterizing its structure and interactions with other proteins, the research aims to elucidate the role of the RZZ in the organization and dynamics of kinetochores, which are critical for accurate gene…
This application is concerned with the structural and functional characterization of the RZZ protein complex, a critical constituent of metazoan kinetochores.
The RZZ, a 400-kDa trimer, is named after the initials of its components, Rod, Zwilch and Zw10.
The RZZ is implicated in the execution of mitosis, the process of equal partitioning of the genetic material.
In mitosis, the sister chromatids attach to spindle microtubules and become aligned at the metaphase plate.
This alignment process is o…
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