CORDIS Project
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This project investigates the role of resolvin D3 in aortic valve stenosis, focusing on its anti-inflammatory and proresolving effects. By analyzing human aortic valve samples and utilizing a preclinical model, the research aims to uncover new therapeutic strategies to manage this condition and improve patient outcomes…
Aortic valve stenosis is a progressive inflammatory disorder with poor prognosis if left untreated.
Currently the only available treatment is invasive surgical replacement of the valve, therefore new therapeutic strategies are needed.
Resolution of inflammation is an active process orchestrated by endogenous specialized proresolving lipid mediators (SPM).
These include the resolvins that actively promote catabasis via their potent actions in anti-inflammation, proresolution, tissue regeneration…
KAROLINSKA INSTITUTET
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