CORDIS Project
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This project investigates the role of histone H2B monoubiquitylation in genome regulation and its implications for cancer. By manipulating the RNF20 protein, the research aims to understand its effects on gene expression, transcription, and cellular differentiation, particularly in cancer-related processes and inflamma…
Chromatin modifications play a major role in regulating genome function.
Perturbations in such modifications can contribute to neoplastic processes.
We will focus on a specific chromatin modification: histone H2B monoubiquitylation.
The significance of monoubiquitylated H2B (H2Bub) will be studied by manipulating RNF20, the major E3 ubiquitin ligase responsible for H2B ubiquitylation as part of a heteromeric complex with RNF40.In one major line of research, we will assess the biochemistry of RNF…
WEIZMANN INSTITUTE OF SCIENCE
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