CORDIS Project
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This project investigates the role of RTP801, a protein linked to neuron death, in Parkinson's disease. It examines how the parkin gene influences RTP801 levels and neuron survival, aiming to understand the mechanisms of neural degeneration and inform potential therapeutic strategies.
In this proposal, we hypothesize that RTP801, a neuron-death associated protein, is a target for parkin in cellular and animal models of Parkinson's disease (PD).
We will test whether parkin regulates the proteasomal degradation of RTP801 and whether parkin loss of function elevates RTP801 to mediate neuron death in cellular and animal models of PD. RTP801 is elevated in cell and animal models of PD and in affected neurons of PD patients.
In PD models, RTP801 up regulation leads to inactivation…
UNIVERSITAT DE BARCELONA
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