CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the mechanisms controlling R-loop accumulation at human telomeres, focusing on their role during DNA replication and in cancer cells. By developing innovative detection methods and analyzing chromatin, the research aims to identify factors that regulate R-loops, potentially leading to new canc…
Telomere stability is essential to prevent tumorigenesis and cellular senescence in human cells.
Telomeres are transcribed into TERRAs, which has the ability to form R-loops with the DNA template.
It is known that R-loops can hamper replication fork progression leading to hyperrecombination and genome instability.
Indeed, R-loops are accumulated in telomeres of cancer cells that use the Alternative Lengthening of Telomere (ALT) maintenance mechanism to gain immortalisation and in ICF syndrome ce…
UNIVERSIDAD DE SEVILLA
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
Guests see up to 5 keywords.
