CORDIS Project
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This project investigates the dynamics of ribosomes using advanced mass spectrometry techniques. It aims to understand ribosome biogenesis and how ribosomal structures change under stress, which could lead to new antibacterial drug developments.
Ribosomes, large and dynamic particles made of RNA and proteins, are amongst the most complex macromolecular machines known to man.
High resolution tools have provided exciting views of the ribosome structure.
Revealing dynamics of ribosomal complexes in solution, however, has so far been challenging due to the restricted stability and homogeneity of ribosomes. A set of new tools developed by the Rappsilber lab, partly by me over the last few months, changes dramatically the feasibility of inves…
THE UNIVERSITY OF EDINBURGH
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