CORDIS Project
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This project investigates the role of specific proteins in the assembly and stability of cilia, which are crucial for various cellular functions. By studying mutations in key proteins, the research aims to understand the molecular mechanisms underlying ciliary motility and its implications for human health.
Cilia are microtubule (MT)-based external cell extensions that perform sensory and locomotory functions.
Disruption of ciliary beating leads to human disorders such as infertility, airways diseases and hydrocephalus.
The central pair of MTs (CP) apparatus is required for proper cilia motility yet the molecular mechanism that regulates its assembly is unknown.
Loss of function mutations of MTs severing protein katanin or changes in the levels of MTs posttranslational modifications (PTMs) result i…
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
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