CORDIS Project
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This project investigates the role of the Mastl kinase in the cell division cycle of mammalian cells, focusing on its function and potential as a target for cancer therapy. It employs various methods, including genetic analysis and proteomics, to explore Mastl's interactions and effects on tumor cells.
The cell division cycle is an essential step in living organisms.
Different studies have led to a model where cell cycle kinases act as major engines to promote cell cycle progression throughout the different phases of the cell cycle.
In addition to Cyclin- dependent kinases (Cdks), Polo-like and Aurora kinases, other kinases have recently emerged as important regulators of cell cycle progression.
Among them, a new kinase known as Mastl in mammals, and Greatwall in Xenopus and Drosophila, has be…
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