CORDIS Project
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This project investigates the role of the p110beta isoform of phosphoinositide 3-kinases in breast cancer cell invasion. It aims to uncover the mechanisms by which p110beta influences cancer cell behavior and endosomal functions, using advanced laboratory techniques and animal models.
PI 3-kinases (PI3Ks) generate lipids in cell membranes which bind a variety of intracellular protein effectors, affecting their localization and/or activity.
The PI3K signalling axis is one of the most frequently deregulated pathways in cancer.
Mammals have 8 isoforms of PI3K, divided into three classes.
The class I PI3Ks consist of a p110 catalytic subunit (p110alpha, p110beta, p110delta and p110gamma) bound to a regulatory subunit.
Recent work has revealed that PI3K isoforms have surprisingly…
QUEEN MARY UNIVERSITY OF LONDON
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