CORDIS Project
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This project investigates the role of the HspB8 protein in managing misfolded proteins linked to neurodegenerative diseases. It explores how HspB8 interacts with other proteins to influence autophagy, aiming to understand its potential in treating conditions like Huntington's disease.
Molecular chaperones and degradation systems allow cells to cope with misfolded and genetically mutated proteins.
The Hsp70/Hsp40 families and the members of the HspB family (HspB1-HspB10) recognize and bind misfolded proteins, prevent their aggregation and facilitate their degradation.
Mutations in genes encoding several HspB proteins have been associated with neurological and muscular disorders, strongly supporting a critical role for these proteins in neuronal and muscular cell viability.
For…
UNIVERSITAIR MEDISCH CENTRUM GRONINGEN
ACADEMISCH ZIEKENHUIS GRONINGEN
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