CORDIS Project
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This project investigates the role of Gadd45 family proteins and p38 in regulating tumor suppression and autoimmunity. By employing various genetic and biochemical techniques, it aims to uncover molecular mechanisms that could lead to new therapeutic targets for diseases like lupus, rheumatoid arthritis, and certain ca…
Gadd45 family proteins play a critical role in genomic stability, cell cycle regulation proliferation and apoptosis.
Gadd45a is activated by the tumor suppressor gene p53, which is mutated in >50% of human tumors.
The lack of GADD45a in mice leads to spontaneous development of an autoimmune disease similar to systemic lupus erythematosus.
The molecular mechanisms that cause autoimmunity are poorly understood.
Recent evidence suggests that p38 activation is involved in autoimmune development and…
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