CORDIS Project
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This project investigates how Bone Morphogenetic Protein signaling regulates microtubules in axons, which are crucial for neuronal health. By studying the mechanisms involved, it aims to enhance understanding of axonal degeneration in hereditary spastic paraplegias and potentially other neurodegenerative diseases.
The hereditary spastic paraplegias (HSPs) are a set of diseases in which longer spinal cord axons degenerate.
The pathological mechanisms of degeneration in HSPs are poorly understood, even in cases when causative genes have been cloned.
To date, some thirty causative loci (SPG loci) have been mapped and thirteen cloned.
The host laboratory has recently identified a mechanism by which one gene product, SPG6, can affect axonal transport.
The Drosophila SPG6 homolog, spichthyin, is a novel antagon…
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