CORDIS Project
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This project investigates the role of hyperpolarisation-activated ion channels in pain perception, particularly in neuropathic pain. By studying genetically modified mice, the research aims to identify which ion channel subunits are involved in sensory neuron responses to painful stimuli.
Pain arises when a stimulus activates a pain-specific nerve fibre by opening an ion channel, causing a depolarisation (positive change in membrane potential) and triggering action potentials that propagate to the central nervous system to elicit a sensation of pain.
The rate of depolarisation between action potentials determines their frequency, and thus the pain intensity.
An important modulator of this rate is the hyperpolarisation-activated inward current, Ih.
Ih ion channels are made up fr…
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