CORDIS Project
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This project investigates the role of cytochrome P450 metabolites, specifically epoxyeicosatrienoic acids, in regulating blood pressure and kidney function. By inhibiting soluble epoxide hydrolase, the research aims to enhance the levels of these metabolites and assess their impact on hypertension and renal health.
Cytochrome P450 (CYP) metabolites are more frequently recognized as important regulators of cardiovascular and renal functions. CYP epoxygenases produce epoxyeicosatrienoic acids (EETs) that exhibit vasodilatory and natriuretic properties. EETs are degraded by the enzyme soluble epoxide hydrolase (sEH).
Inhibition of sEH increases the level of EETs and attenuates blood pressure (BP) and end organ damage in several models of hypertension.
We would like to define the role of EETs in BP regulation…
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