CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the role of Collapsin Response Mediator Protein 2 (CRMP2) in Alzheimer's disease, focusing on how its different forms contribute to the formation of protein aggregates. It aims to understand the influence of specific proteins and peptides on CRMP2's stability and function using mouse models.
Collapsin response mediator protein 2 (CRMP2) is essential for neural development and function.
It promotes axon growth but upon its phosphorylation it mediates axon retraction.
Deregulation of CRMP2 has been implicated in Alzheimer’s disease (AD) where CRMP2 was detected to form hyperphosphorylated aggregates within neurofibrillary tangles.
The mechanisms that regulate formation of CRMP2 aggregates are so far largely unknown.
We have recently found that one CDK5-phosphorylated CRMP2 isoform is…
UMG INSTITUTE OF MOLECULAR GENETICS ACA SCIEN CZECH REPU
USTAV MOLEKULARNI GENETIKY AV CR V.V.I.
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
