CORDIS Project
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This project investigates the reprogramming of induced pluripotent stem cells (iPSCs) to enhance efficiency in medical research. It focuses on identifying gene expression patterns and chromatin changes during reprogramming, aiming to uncover essential stages that lead to pluripotency and improve reprogramming technique…
Induced pluripotent stem cells (iPSCs) are expected to have an enormous impact on medical research.
However, the efficiency of reprogramming is still low and far from routine.
Nevertheless, reprogramming with defined factors, Oct4, Sox2, Klf4 and c-Myc, is not a random event.
Cells positive for SSEA-1, a marker of undifferentiated mouse ES cells (ESC), appear from cells which have lost the fibroblast marker Thy-1, prior to acquiring other pluripotent markers, e.g.
Oct4, Nanog.
Similarly, TRA-1-6…
THE UNIVERSITY OF EDINBURGH
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