CORDIS Project
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This project investigates how mutations in RNA viruses affect their fitness, focusing on deleterious mutations that can lead to viral extinction. By utilizing advanced sequencing techniques, the research aims to understand the distribution of fitness effects and explore how environmental changes influence mutation accu…
Mutations are fundamental drivers of evolution.
Characterizing how mutations affect fitness is critical across diverse fields: from pathogen biology, to human genetic diseases, and models of population extinction. RNA viruses, notorious for their high mutation rates and rapid generation times, are ideal models for studying the effects of mutations.
To date, deleterious mutations (i.e., mutations with a fitness cost) have been understudied as compared to beneficial mutations, mainly since it has…
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