CORDIS Project
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This project focuses on understanding the process of mRNA export from the nucleus to the cytoplasm in human cells. By employing advanced structural biology techniques, it aims to elucidate how specific proteins recognize and package mature mRNA for translation, enhancing our knowledge of gene expression regulation.
Eukaryotic gene expression is partitioned across two cellular compartments: the nucleus, where messenger RNA (mRNA) is produced, and the cytoplasm, where protein translation occurs. mRNA export across the nuclear membrane is highly selective, ensuring that only fully processed and mature mRNA is transported to the cytoplasm.
Yet how does the multi-step mRNA maturation process converge to a binary decision, ‘to export or not to export’?
While we know many of the proteins involved in packaging and…
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