CORDIS Project
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This project aims to enhance RNA replicons for vaccine delivery by minimizing the immune response that limits their effectiveness. Through molecular modifications and innovative delivery methods, it seeks to improve protein expression and scalability of RNA-based therapies.
As a Maria Skłodowska-Curie Fellow, I aim to develop formulated next-generation RNA replicons that are designed to overcome the limiting initial type I interferon response that inhibits amplification and protein expression.
RNA replicons are currently a cutting edge nucleic acid platform for delivery of vaccines and therapeutics, as they do not require penetration into the nucleus like plasmid DNA, but possess self-amplification properties that results in more efficient protein expression than m…
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