CORDIS Project
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This project aims to uncover how non-coding RNA regulates gene expression, specifically focusing on a mechanism that silences HIV-1 transcription. It investigates the role of small RNAs and their interactions with transcription factors in human cells.
More than 70% of the human genome synthesizes non-coding RNA that is believed to regulate gene expression.
While there is ample evidence from model systems that small RNAs are the lynchpin of powerful mechanisms that silence transcription, the demonstration of transcriptional gene silencing (TGS) mediated by a small RNA in humans is lacking.
We have recently shown that the HIV-1 LTR is controlled by premature termination of transcription and TGS mediated by a small RNA derived from the stem-loop…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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