CORDIS Project
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This project investigates the mechanisms of epigenetic inheritance in animals, focusing on small RNA molecules and histone modifications. Using the nematode Caenorhabditis elegans as a model, it aims to uncover how these factors influence developmental programs and are transmitted across generations.
Inherited information is transmitted to progeny primarily via the genome through the gametes.
In recent years, epigenetic inheritance has been demonstrated in several organisms, including animals.
Yet, the molecules and mechanisms responsible for this type of inheritance are incompletely understood.
Histone modifications, DNA methylation, and small RNAs have been proposed to participate in epigenetic inheritance.
Indeed, we recently showed how the inheritance of a specific type of small RNA im…
INSTITUT PASTEUR
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