CORDIS Project
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This project investigates the antiviral RNA interference mechanisms in insects, particularly focusing on the fruit fly. It aims to understand how insects utilize RNA to combat viral infections and the dynamics of their immune response.
RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that is induced by double-stranded RNA (dsRNA).
Double-stranded RNA is commonly generated during viral replication and is considered to be a molecular pattern associated with viral infection.
Our previous work demonstrated that viral infections in the fruit fly Drosophila melanogaster are countered by an antiviral RNAi response: the small interfering RNA (siRNA) pathway is the major antiviral defence mechanism in…
INSTITUT PASTEUR
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