CORDIS Project
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This project focuses on understanding the RNA-induced silencing complex (RISC) and its role in gene regulation. Using advanced single-molecule fluorescence techniques, it aims to reveal the dynamics of RISC action, which could enhance RNA-based therapies by minimizing off-target effects.
Recent groundbreaking discoveries have changed our view on RNA from that of a passive information carrier to an important regulatory element.
MicroRNA is a small regulatory RNA that controls nearly all mRNAs in eukaryotic cells.
Since this regulation process (termed RNA interference/RNAi) occurs in a sequence-specific manner, we can manipulate gene expression using custom-designed small RNAs.
This remarkable discovery introduced the possibility of RNA-based gene therapy and triggered intensive r…
TECHNISCHE UNIVERSITEIT DELFT
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