CORDIS Project
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This project explores the role of enhancer-derived RNAs in gene regulation by studying their production and processing in rat cortical neurons. It aims to clarify the mechanisms of eRNA function and its impact on gene expression.
Enhancers are short distal cis-regulatory DNA regions that drive expression of a gene.
However, enhancers do not function exclusively as DNA entities.
Activated enhancers are transcribed by RNA polymerase II (RNAPII), which produces enhancer-derived RNAs (eRNAs).
Production of eRNA creates additional trans-regulatory mechanisms facilitated by DNA-RNA, RNA-RNA, or protein-RNA interactions.
Due to eRNAs fast degradation rates, and lack of robust and standardized sequencing methods, reports about t…
TALLINN UNIVERSITY OF TECHNOLOGY
TALLINNA TEHNIKAÜLIKOOL
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