CORDIS Project
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The project aims to control eukaryotic messenger RNA translation using light, enabling precise manipulation of gene expression in cells and developing organisms. By photo-caging the mRNA, it seeks to enhance the efficiency of ectopic translation and study its effects on cell fate.
Light is an excellent external regulatory element that can be applied to cells and organisms with high spatio-temporal precision and without interfering with cellular processes.
Optochemical biology exploits small photo-responsive chemical groups to cage and activate or to switch biomolecular functions in response to light of a defined wavelength.
Caged antisense agents have enabled down-regulation of gene expression with spatio-temporal control at the messenger-RNA (mRNA) level in vivo, however…
UNIVERSITAET MUENSTER
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