CORDIS Project
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This project aims to structurally characterize a specific region of a group II intron ribozyme from yeast mitochondria using nuclear magnetic resonance. By studying its interactions with metal ions and other domains, the research seeks to enhance understanding of ribozyme function and evolution in the context of RNA bi…
Group II introns are one class of naturally occurring catalytic RNAs, ranging between 600 and thousands of nucleotides in length.
These ribozymes catalyze a variety of reactions, among which the self splicing activity is the most prominent one.
These large molecular machines are found primarily in organellar genes of plants, fungi and lower eukaryotes, but also in many bacteria.
Metal ions are crucial for folding and activity of catalytic RNA molecules, however their structural and mechanicistic…
University of Zurich
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