CORDIS Project
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This project investigates non-enzymatic RNA replication mechanisms in prebiotic systems, focusing on the role of protocellular compartments. It aims to understand how these compartments can facilitate RNA amplification, contributing to the origins of life.
Deciphering how nucleic acids replicated in the absence of genetically encoded enzymes is of critical importance to understanding the onset of Darwinian evolution.
While much effort has been put into developing chemically-driven copying of RNA exploiting activated monomers, many unsolved issues stand in the way of achieving repeated cycles of non-enzymatic RNA replication.
Non-enzymatic copying of a template strand results in the formation of an RNA duplex, which must then be denatured in order…
UNITED KINGDOM RESEARCH AND INNOVATION
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