CORDIS Project
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This project investigates the mechanisms behind the localization and translation of specific messenger RNAs in neurons, which is crucial for proper brain function. By utilizing advanced imaging and molecular tools, it aims to understand how mRNA dysregulation contributes to neurodegenerative diseases like amyotrophic l…
Brain function requires precise regulation of the neuronal proteome which involves localizing thousands of mRNAs to neurites, where specific subsets are translated at the required subcellular locations.
Although local translation is well-established, the mechanisms that ensure the capture and translation of specific mRNAs at the correct subcellular location remain elusive. A better understanding of this process is urgent since dysregulation of mRNA localization and translation is emerging as a k…
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