CORDIS Project
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This project investigates the role of a specific protein, RGS1, in regulating immune responses in the gut. By understanding how RGS1 affects T cell behavior, the research aims to uncover new treatment strategies for inflammatory bowel disease and other related conditions.
The intestine is a challenging site for the immune system, which must balance the need to defend from pathogens, with the need to limit responses to commensals and to preserve tissue integrity.
Nonetheless, few mechanisms have been defined by which the regulation of gut T cell responses may be distinguished from systemic T cell regulation. RGS1 is one of the most differentially expressed gene-products between gut-associated and lymphoid T cells, and yet there has been essentially no study of its…
CANCER RESEARCH UK LBG
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