CORDIS Project
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This project investigates the role of Toll-like receptors in the female reproductive tract and their impact on implantation success. It aims to understand how sex hormones influence these receptors and develop models to improve infertility diagnosis and treatment.
Implantation failure after natural mating or in vitro fertilization may be due to either embryo or endometrial factors.
Recent evidence suggests that sub-clinical infection, inflammation or malfunctions of the immune system in the female reproductive tract (FRT) are major causes of implantation failure.
Toll like receptors (TLRs) have been shown to have a key role in the induction of immune and inflammatory responses in mammals. TLRs are the main family of pattern recognition receptors, they rec…
THE UNIVERSITY OF SHEFFIELD
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