CORDIS Project
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This project investigates the role of Shiftless (SFL), a factor that inhibits programmed ribosomal frameshifting (PRF) in viruses like HIV and coronaviruses. By understanding how SFL interacts with viral mRNAs and ribosomes, the research aims to inform the development of new antiviral therapies targeting these critical…
Programmed ribosomal frameshifting (PRF) is a mechanism of recoding that allows synthesis of multiple proteins from the same mRNA by shifting the translation reading frame.
Many viruses, including medically important HIV and coronaviruses rely on PRF to increase their coding capacity and modulate appropriate stoichiometric ratios of viral proteins.
An interferon-inducible restriction factor Shiftless (SFL) can block the frameshifting required for viral translation and infectivity.
Understanding…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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