CORDIS Project
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This project investigates how cells rescue stalled ribosomes on the endoplasmic reticulum during stress. It focuses on the role of autophagy and specific receptors in maintaining protein synthesis and cellular function in both plants and humans.
Multiple ribosomes simultaneously move along the mRNAs to translate the genes into proteins.
Cellular stress triggers collisions of ribosomes and disrupts protein synthesis.
Eukaryotes have evolved multi-tiered quality control mechanisms that monitor ribosomes and rescue them on collision.
While much is known about the rescue of cytosolic ribosomes, how the cell rescues stalled endoplasmic reticulum bound (ER-bound) ribosomes remains unknown.
We recently discovered that the stalling of ER-bound…
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
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Austria, Wien
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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