CORDIS Project
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This project investigates the roles of maternal and somatic ribosomes during zebrafish embryogenesis. By analyzing their translation activities, it aims to uncover the regulatory mechanisms that influence early development in vertebrates.
The process of embryogenesis involves coordinated changes in gene expression at both transcriptional and translational levels.
In zebrafish, translation at early stages of embryo development relies on maternal, oocyte-derived ribosomes which are completely replaced by newly synthesized somatic ribosomes within 5 days after fertilization.
Strikingly, preliminary data obtained in the Pauli lab suggest that maternal and somatic ribosomes diverge not only in rRNA content but also in protein composit…
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