CORDIS Project
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This project investigates the role of non-coding RNAs in gene expression and chromatin structure regulation, focusing on the NoRC complex and its associated RNAs. It aims to understand how these RNAs influence epigenetic control of ribosomal DNA and their implications for cell growth and differentiation.
Non-coding RNAs (ncRNAs) play a significant role in the control of gene expression and epigenetic regulation.
It seems that ncRNAs might be numerous and highly adapted in roles that require specific nucleic acid recognition without complex catalysis, such as in guiding RNA modifications or in directing post-transcriptional regulation of gene expression and chromatin structure.
Our previous work has revealed that NoRC, a chromatin remodeling complex that triggers heterochromatin formation and tra…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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