CORDIS Project
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This project investigates how proteins fold and assemble in cells, focusing on the role of ribosomes in coordinating these processes. By exploring co-translational folding and degradation mechanisms, the research aims to enhance understanding of protein misfolding diseases and develop new therapeutic strategies.
The majority of cellular proteins do not function alone; rather acting together to achieve concerted functions.
Despite the prevalence of protein complexes, little is known of the mechanisms that ensure their correct folding and assembly in the crowded cytoplasm.
The importance of the folding challenge is underscored by the growing number of misfolding diseases, often characterized by aggregation of lonely, unassembled protein-subunits.
At the critical intersection of synthesis and folding, the…
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