CORDIS Project
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This project focuses on identifying and characterizing new classes of riboswitches, which are RNA elements that regulate gene expression in bacteria. By discovering novel riboswitch-ligand interactions, the project aims to develop innovative antibiotics to combat bacterial drug resistance.
Riboswitches are mRNA-based gene-regulatory elements triggered by direct interactions with small molecular ligands.
They are exciting targets for novel antibiotic strategies.
Many putative riboswitches have been identified using bioinformatics.
However, ligand identification is getting more complicated since many motifs are not expected to be involved in simple feedback regulation mechanisms.
For such “classical” riboswitches ligands have been assigned in the past based on testing metabolites se…
UNIVERSITAT KONSTANZ
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