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RhoSNATCH investigates Rho GTPase signaling in live fibroblast cells to understand how these proteins coordinate cell migration. By using advanced imaging and microfluidic technologies, the project aims to reveal the complex interactions and dynamics of Rho GTPases that influence cytoskeletal behavior in real-time.
Recent advances in technologies to measure Rho GTPase signaling with unprecedented spatiotemporal resolution in single living cells have led to novel questions.
Important new insights are that Rho GTPase signaling involves the formation of signaling complexes that fluctuate on subminute time and micrometer length scales, and that complex signaling networks involving multiple Rho GTPases fine tune the leading edge dynamics that power fibroblast migration.
Novel methodologies are required to disse…
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