CORDIS Project
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This project investigates how rhomboid-like proteins regulate immune cell signaling and protein trafficking. By studying the interactions of RHBDL4 and iRhom2 in human myeloid cells, the research aims to provide insights into immune responses and potential therapeutic targets.
The immune system coordinates vital responses against a plethora of threats.
It relies on well-described signalling networks via soluble proteins and cell-to-cell contacts.
The secretory pathway traffics all secreted and surface proteins, but the mechanism of how immune cells control this process is unclear.Rhomboid-like proteins are a family of polytopic intramembrane proteins serine proteases and pseudoenzymes found in all organisms.
Most eukaryotic rhomboid-like proteins regulate the fate of…
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