CORDIS Project
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The project investigates the evolutionary history and functional diversity of RNA-guided nucleases (RGNs) by reconstructing their ancestral forms. It aims to uncover how these ancestors contributed to the development of modern RGNs and to enhance their applications in genome editing and molecular diagnostics.
The phylogenetic, biochemical and functional diversity of these linked RGNs suggest a common origin that gave rise to the innumerable variations we observe today.
However, little is known about these ancestors and the evolutionary paths that led to their modern counterparts.
Recently, our team showed that reconstructed ancestors of Cas9 and Cas12a RGNs exhibit flexible substrate recognition and collateral activities distinct from any modern counterpart.
This work sets the stage to uncover the ev…
Botnar Institute of Immune Engineering
FOUNDATION IMMUNE ENGINEERING FOR GLOBAL CHILD AND ADOLESCENT HEALTH
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TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
United States, New York
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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