CORDIS Project
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This project investigates the role of the transcription factor Zeb2 in liver sinusoidal endothelial cells, which are crucial for liver regeneration. It aims to understand Zeb2's impact on cell specification and its potential therapeutic applications in liver disease recovery.
The liver is a crucial organ in metabolism and removal of waste products from the body.
Hereto, the liver parenchyma receives a mix of nutrient-rich blood from the portal vein and oxygen-rich blood from the hepatic artery.
Blood flows through the sinusoids and leaves the liver via the central and hepatic veins.
Hepatic sinusoids are highly specialised channels in which hepatocytes are organised in zones according to their position relative to the portal and central veins.
They are lined with a s…
KATHOLIEKE UNIVERSITEIT LEUVEN
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