CORDIS Project
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This project develops a software solution that integrates biomarkers to predict the effectiveness of hypoxia-activated prodrugs in cancer treatment. It focuses on identifying tumor hypoxia and homologous recombination deficiency to enhance therapy outcomes.
Hypoxia-activated prodrugs (HAPs) are a great concept in particular in association therapies more efficient on well-oxygenated cells, such as immunotherapies. CP-506 is a third generation HAP with optimal PK for which we confirmed in more than 20 tumor models that presence of tumor hypoxia is a requisite for prodrug activation.
We already had an AI/radiomics-based proprietary IP on a solution to identify hypoxia from standard imaging.
Another important determinant for efficacy was the presence o…
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