CORDIS Project
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This project develops a human model of Calcifying Aortic Valve Disease to investigate how the disease alters the extracellular matrix. By creating a specialized imaging platform, it aims to visualize the molecular changes and mineralization processes in real-time, potentially leading to new drug therapies for heart val…
Calcifying Aortic Valve Disease (CAVD) is a cellular-driven disease that actively alters the structure and composition of the valve extracellular matrix, leading to severe disfunction of the heart.
Because the molecular mechanisms underlying CAVD are still unknown, there are currently no drug-based therapies and valve replacement is the only available treatment.Specifically, it is still unknown (1) how the disease modifies the extracellular matrix (ECM) to become susceptible for mineralization,…
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
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