CORDIS Project
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This project investigates retrotransposons, which are repetitive sequences in the human genome that can cause genetic diseases and cancer. It aims to understand the cellular pathways regulating their activity, the mechanisms of their replication, and their role in genome remodeling, particularly in tumors.
Retrotransposons are a class of highly repetitive sequences, which are very abundant in the human genome.
They disperse by an RNA-based copy-and-paste mechanism, called retrotransposition.
This process can drive profound genome rearrangements.
Although generally silent, they are expressed in germ cells, in the early embryo, and in embryonic stem cells, which occasionally results in genetic diseases.
Retrotransposons are also massively re-expressed in the large majority of cancers, but the import…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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