CORDIS Project
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This project investigates how endogenous retroelements (EREs) are repurposed by tumor cells to enhance cancer growth. By mapping ERE transcription and identifying their roles in cancer and immunity, the research aims to uncover new therapeutic targets for cancer treatment.
Exaptation, the co-option of endogenous retroelements (EREs) for new molecular and cellular functions that confer a host fitness advantage, is a major force in evolution, but may also be exploited, through onco-exaptation, by tumour cells to promote the oncogenic process.
There are over 4 million well-recognised and annotated individual ERE integrations in the human genome.
However, their participation at the level of the more complex transcriptome is far less well understood and, therefore, the…
THE FRANCIS CRICK INSTITUTE LIMITED
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