CORDIS Project
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This project investigates diversity-generating retroelements (DGRs), which are genetic elements that can mutate specific regions of a host genome. The research aims to understand DGR function and its potential applications in biotechnology and medicine through the development of new experimental assays.
Retroelements are genetic elements that use reverse transcriptase to insert DNA copies of their RNA into new locations in the host genome.
They are found in all realms of life and are one of the major agents shaping genomes. A newly discovered class of viral and bacterial retroelements, the diversity-generating retroelements (DGRs), have the unusual ability to repeatedly target and mutagenize a defined region of the host genome.
This process is conceptually similar to the antibody diversificatio…
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