CORDIS Project
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This project focuses on understanding how retroviruses, particularly HIV-1, interact with host genomes during infection. It aims to explore the mechanisms of viral DNA integration and gene expression, which could lead to safer gene therapy applications using lentiviral vectors.
Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in the nucleus.
The three-dimensional (3D) organization of chromosomes profoundly affects DNA functions, primarily transcription.
During retroviral infection, histone-free viral DNA copy is synthesized from viral genomic RNA. vDNA will ultimately integrate into the host genome to ensure its maintenance and expression.
Understanding retrovirus-host interactions at the genomic level, and the peculiar mechanisms by…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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